pentobarbital will minimize the extent or result of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; steer clear of use in people who're chronically applying a strong CYP3A4 induceroverall health centers / snooze Heart/nembutal pen